报告人：徐衍聪教授（中国计量大学）

报告时间：2024年11月14日下午3:00-4:00

报告地点：数学楼467室

题目：A dynamical system view of p53 dynamics triggered by DNA damage

摘要：In this paper, a p53-Mdm2 network model with Michaelis–Menten function involved in DNA damage repair is studied by using the dynamical system approach. Detailed bifurcations of the model including saddle-node bifurcation, Hopf bifurcation of codimension 3, and cusp-type Bogdanov–Takens bifurcation of codimension 3 are investigated. To our best knowledge, it is thefirst time that the coexistence of an isola and a cusp of limit cycles is observed for the p53 model, which indicates complex transitions of different oscillating dynamics. Furthermore, wefind that oscillation could persist whether the damage is nonexistent, small or large, and multiple oscillations can be involved in the DNA repair process. In addition, the dynamics induced by the interaction between p53 and Mdm2 unveil the relationship between the positive feedback brought by p53 itself and the negative feedback brought by Mdm2, which triggers the digital oscillation modes for DNA damage.

个人简介：徐衍聪，中国计量大学理学院教授，博士生导师，华东师范大学应用数学专业博士，浙江大学博士后，美国工业与应用数学学会会员，美国数学会会员，浙江省数理医学会理事，浙江省ZSMM生物医学数学专业委员会主任，曾入选浙江省优秀中青年骨干教师，杭州市优秀教师，校优秀中青年支持计划，校教学十佳，校十佳班主任等。先后访问美国布朗大学，德国不莱梅大学，日本京都大学，加拿大约克大学等高校。主持国家自然科学基金面上项目、天元基金、日本全球卓越中心（GCOE）项目，归国留学基金、博士后基金、浙江省自然科学基金等。目前主要从事动力系统分支理论及应用研究。