Title: Statistical design and analysis of response adaptive clinical trials
Abstract: The talk introduces statistical design and analysis of clinical trials in medicine and the pharmaceutical industry. The focus is on the currently important and popular research area of response adaptive design of clinical trials, the goal of which is to improve the ethics and efficiency without undermining the validity and integrity of the clinical research. The key approach is to apply the method of response adaptive randomization, which adaptively adjusts the randomization probability of the next treatment assignment according to sequentially accrued information. The talk discusses the various challenges and their solutions about statistical design and analysis of response adaptive randomization.